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Updated: Jan 18, 2026

Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

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Published on: April 26, 2024

CD38 connects the heart and brain.

Yijing Tao^1,2, Jiahao Duan¹, Kai Huang¹

¹Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.

Translational Psychiatry

|September 11, 2025

Summary

This summary is machine-generated.

Cluster of differentiation 38 (CD38) plays a key role in heart and brain functions. Inhibiting CD38 may offer protection against cardiovascular diseases and neurological disorders.

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Area of Science:

Biochemistry
Cardiology
Neurology

Background:

Cluster of differentiation 38 (CD38) is a transmembrane glycoprotein with significant roles in cardiac and neural tissues.
CD38 influences key cellular processes including calcium signaling, NAD+ metabolism, oxidative stress, and immune responses.

Purpose of the Study:

To review the expression patterns, regulatory mechanisms, and signaling pathways of CD38 in the heart and brain.
To explore the implications of CD38 in coexisting cardiovascular and neurological diseases.

Main Methods:

Literature review of studies on CD38 expression and function.
Analysis of CD38's role in cardiovascular and neurological disease pathogenesis.

Main Results:

CD38 exhibits diverse biological activities, including NADase and cyclase functions, impacting heart and brain health.
CD38 is involved in pathways linked to cardiovascular diseases (CVD) and neurological disorders.

Conclusions:

CD38 is implicated in the shared pathogenesis of heart-brain diseases.
Targeting CD38 presents a potential therapeutic strategy for managing combined cardiovascular and neurological conditions.