Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle Regeneration Failure May Lead to Clinical Features of Myopathy in Anti-IgLON5 Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

A new Patient-Reported Outcome Scale to assess autoimmune Encephalitis: PROSE.

Annals of neurology·2026
Same author

Reply: Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026
Same author

NMDAR-antibody encephalitis: Seizure semiology and EEG findings.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Isolated Peripheral Nervous System Presentation in Ma/Ma2-Associated Autoimmunity.

Neurology(R) neuroimmunology & neuroinflammation·2026

Related Experiment Video

Updated: Jan 18, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.5K

Autoimmune encephalitis.

Marienke A A M de Bruijn1,2, Frank Leypoldt3,4, Josep Dalmau5,6,7,8

  • 1Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Nature Reviews. Disease Primers
|September 11, 2025
PubMed
Summary

Autoimmune encephalitis (AE) is a treatable neuroinflammatory disorder. Early diagnosis and treatment, including immunosuppression or tumor management, improve patient outcomes and recovery, despite potential long-term effects.

More Related Videos

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.7K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.3K

Related Experiment Videos

Last Updated: Jan 18, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.5K
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.7K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.3K

Area of Science:

  • Neuroimmunology
  • Neurology

Background:

  • Autoimmune encephalitis (AE) is an increasing neuroinflammatory disorder.
  • AE can be paraneoplastic or idiopathic, presenting heterogeneously based on antibody targets.
  • Antibodies against extracellular antigens (e.g., NMDAR) cause synaptic dysfunction, while intracellular antigen antibodies (e.g., Hu) are often paraneoplastic.

Purpose of the Study:

  • To summarize the current understanding of autoimmune encephalitis, including its causes, presentation, diagnosis, and treatment.
  • To highlight the importance of early recognition and intervention for improved patient outcomes.
  • To outline current research directions aimed at enhancing treatment and long-term recovery.

Main Methods:

  • Review of existing literature on autoimmune encephalitis.
  • Analysis of disease presentation, autoantibody targets, and treatment strategies.
  • Discussion of diagnostic criteria and prognostic factors.

Main Results:

  • AE presents with diverse neurological symptoms like cognitive decline, behavioral changes, and seizures.
  • Diagnosis relies on identifying autoantibodies, though seronegative cases exist.
  • Treatment involves immunosuppression for antibody-mediated AE and tumor treatment for paraneoplastic cases.

Conclusions:

  • Prompt diagnosis and treatment of AE are crucial for better outcomes.
  • While recovery is often good, residual symptoms can impact quality of life.
  • Ongoing research seeks to refine understanding, diagnostics, and therapeutics for AE.