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Updated: Jan 18, 2026

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

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Published on: September 27, 2011

Charge-Dependent Fluorescence Lifetime Modulation in a Plasmonic Nanocavity.

Alexey I Chizhik¹, Damir I Sakhapov¹, Ingo Gregor¹

¹Third Institute of Physics (Biophysics), Georg August University, 37077 Göttingen, Germany.

The Journal of Physical Chemistry Letters

|September 12, 2025

Summary

This summary is machine-generated.

Researchers developed a new method using plasmonic nanocavities to precisely measure single-molecule electric charges in solution. This technique offers a simple, rapid, and calibration-free alternative for charge quantification.

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Last Updated: Jan 18, 2026

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Published on: September 27, 2011

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Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection

Resonance Fluorescence of an InGaAs Quantum Dot in a Planar Cavity Using Orthogonal Excitation and Detection

Published on: October 13, 2017

Area of Science:

Physical Chemistry
Biophysics
Nanotechnology

Background:

Molecular electric charges are crucial for biomolecular structure and function.
Accurate single-molecule charge measurement is technically challenging.
Existing methods lack sensitivity and simplicity.

Purpose of the Study:

To introduce a novel experimental methodology for quantifying molecular electric charges.
To achieve high sensitivity in charge measurements at the single-molecule level.
To provide a calibration-free and rapid alternative to current techniques.

Main Methods:

Utilizing plasmonic nanocavities to confine charged molecules.
Applying an external electric field to induce molecular redistribution.
Measuring fluorescence lifetime modulation for sensitive readout.
Validating experimental data with theoretical frameworks (statistical thermodynamics, electrodynamics).

Main Results:

Demonstrated proof-of-concept for measuring fluorescence lifetimes of charged dye molecules.
Quantified molecular charges as a function of applied electric field.
Experimental results were rigorously validated by theoretical modeling.
Achieved high sensitivity in charge detection within nanocavities.

Conclusions:

The developed method enables precise quantification of molecular electric charges in solution.
Plasmonic nanocavity-induced fluorescence lifetime modulation is a viable readout.
This technique offers a simple, rapid, and calibration-free approach for single-molecule charge analysis.
Opens new avenues for studying molecular charge dynamics.