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Exploring efficient therapy for cutaneous neoplasm using gel formulations.

Usha D H1, Keerthy H S1

  • 1Department of Pharmaceutics, Mallige College of Pharmacy, Bangalore, India.

Drug Development and Industrial Pharmacy
|September 12, 2025
PubMed
Summary

Gel-based drug delivery systems offer a promising solution for localized skin cancer treatment. These advanced systems improve drug stability, controlled release, and reduce toxicity for better patient outcomes.

Keywords:
Cutaneous neoplasmsgelhydrogelliposome gelnanogel

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Area of Science:

  • Dermatology and Pharmaceutical Sciences

Background:

  • Cutaneous neoplasms (skin cancers) are a growing global health concern, with increasing incidence linked to UV exposure and lifestyle factors.
  • Conventional treatments like chemotherapy and radiation often suffer from systemic toxicity, drug resistance, and poor penetration of the skin barrier.

Purpose of the Study:

  • To review the pathology and treatment of cutaneous neoplasms.
  • To highlight the limitations of conventional therapies.
  • To explore the potential of gel-based drug delivery systems for efficient localized skin cancer treatment.

Main Methods:

  • Review of existing literature on skin cancer pathology, conventional treatments, and gel-based drug delivery systems.
  • Analysis of the advantages of hydrogels, nanogels, and liposome gels in drug delivery for skin cancer.
  • Examination of stimuli-responsive gels for optimized drug absorption and therapeutic efficacy.

Main Results:

  • Gel-based systems enhance drug stability, enable controlled release, and reduce adverse effects compared to conventional methods.
  • These systems improve drug retention and targeted delivery, overcoming poor skin barrier penetration.
  • Stimuli-responsive gels further optimize drug absorption and therapeutic efficacy by reacting to environmental factors like pH and temperature.

Conclusions:

  • Gel-based drug delivery systems represent a significant advancement in treating localized skin cancer.
  • They offer more effective and patient-friendly therapeutic strategies by improving drug delivery and minimizing side effects.
  • These innovations hold the potential to substantially improve patient outcomes in cutaneous neoplasm therapy.