Relative safety of glyphosate-resistant maize (CC-2) in rats

With the rapid adoption of glyphosate-resistant (GR) crops by farmers, the food safety has garnered significant attention. This study aims to evaluate the relative safety of glyphosate-resistant maize (CC-2). Rats were divided into three groups: one group receiving AIN-93 G feed (AIN), one receiving non-modified receptor maize feed (NM), and the other receiving CC-2 maize feed (GM). The intervention spanned from gestation d 0 of the parental rats to 90 d post-weaning of the offspring. The results indicated no significant differences in pregnancy outcomes, body weight, growth monitoring, behavioral tests, or organ indexes between the GM group and the two control groups (AIN and NM). Although there were significant differences in some hematological parameters, serum chemistry, and organ weights, histopathological analysis revealed no abnormalities. No exogenous gene fragments were detected in major organs. In conclusion, CC-2 maize is relative safe for growth and development in rats.