Related Experiment Video
Updated: Jan 18, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A two-decade overview of oxadiazole derivatives as promising anticancer agents
Mo'men Salem1, Khaled El-Adl2,3, Ahmed El-Morsy4,5
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Arish branch Arish Egypt.
Abstract:
One of the most difficult illnesses that people today must deal with is cancer. It is distinguished by aberrant cell division and growth, which results in the development of tumors and lumps. The heterocyclic nucleus has drawn a lot of interest in the field of chemotherapeutics; moreover, it is essential in medicinal chemistry. Oxadiazole is a nitrogen-oxygen heterocyclic core with five members that exhibits remarkable anticancer properties. Inhibiting different enzymes and growth factors is the mechanism linked to tumor defeat. This review has covered research conducted over the past 20 years as well as their potential applications in drug development as antineoplastic agents, given the significance of oxadiazole and its derivatives in this global panic problem. This review aims to highlight the anticancer properties of 1,3,4-oxadiazole and its derivatives, 1,2,4-oxadiazole.
More Related Videos
09:20Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
07:40A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers
Inhibition of Cdk Activity
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...