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Discoidin Domain Receptor 2 (DDR2) Promotes Prostate Cancer Progression in Cooperation with Collagen Remodeling.
Mikoto Sagehashi1, Kiyoshi Takagi1, Ai Sato1
1Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Acta Histochemica Et Cytochemica
|September 12, 2025
Summary
Discoidin domain receptor 2 (DDR2) is linked to aggressive prostate cancer and poor outcomes. This receptor interacts with collagen type I, promoting cancer cell growth and migration.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Prostate cancer is a leading malignancy in men.
- Extracellular matrix remodeling, particularly collagen type I, influences prostate cancer progression.
- Discoidin domain receptor 2 (DDR2), a collagen type I receptor, plays a role in cell signaling but its significance in prostate cancer is underexplored.
Purpose of the Study:
- To investigate the clinical and biological significance of DDR2 in prostate cancer.
- To correlate DDR2 and collagen type I expression with clinicopathological characteristics and patient outcomes.
- To explore the role of DDR2 in prostate cancer cell proliferation and migration in vitro.
Main Methods:
- Immunohistochemical localization of DDR2 and collagen type I in 117 prostate carcinoma tissues.
- Correlation analysis of DDR2/collagen I immunoreactivity with clinicopathological features.
- In vitro experiments using human prostate cancer cell lines (PC-3 and DU-145).
Main Results:
- DDR2 immunoreactivity was associated with an aggressive prostate cancer phenotype.
- DDR2 expression correlated with dense collagen type I tissues composed of thin fibers.
- DDR2 immunoreactivity significantly correlated with adverse clinical outcomes.
- In vitro studies showed DDR2 promotes proliferation and migration of prostate cancer cells.
Conclusions:
- DDR2 is a potential prognostic factor in prostate cancer.
- DDR2 may promote prostate cancer progression through interaction with collagen I.
- Targeting DDR2 could be a therapeutic strategy for prostate cancer.
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