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Antisperm antibodies and in vitro fertilization failure
Journal of in Vitro Fertilization and Embryo Transfer : IVF
|December 1, 1985
Summary
A new enzyme-linked immunosorbent assay detected antisperm antibodies in 33% of patients undergoing in vitro fertilization and embryo transfer (IVF-ET). These antibodies were linked to fertilization issues, suggesting preliminary screening is crucial for IVF-ET success.
Area of Science:
- Reproductive Immunology
- Assisted Reproductive Technology
Background:
- Antisperm antibodies can impact fertility.
- In vitro fertilization and embryo transfer (IVF-ET) is a common treatment for infertility.
Purpose of the Study:
- To investigate the prevalence of antisperm antibodies in patients undergoing IVF-ET.
- To determine the association between antisperm antibodies and fertilization outcomes in IVF-ET.
Main Methods:
- An enzyme-linked immunosorbent assay (ELISA)-based test was used to detect antisperm antibodies.
- Fertilization morphology was observed in patients with and without antisperm antibodies.
Main Results:
- Antisperm antibodies were present in 33% of the 32 patients studied.
- A significant association was found between antisperm antibodies, cumulus/corona coagulation, and the absence of fertilization (P <= 0.025).
Conclusions:
- The presence of antisperm antibodies is linked to impaired fertilization in IVF-ET.
- Antisperm antibody testing should be a routine preliminary screening for patients entering IVF-ET programs.
- Interventions like cumulus/oocyte complex washing or enzymatic removal may be considered for patients with antisperm immunity.