Related Experiment Video
Updated: Jan 18, 2026

10:39
Multimodal Optical Microscopy Methods Reveal Polyp Tissue Morphology and Structure in Caribbean Reef Building Corals
Published on: September 5, 2014
12.8K
Crossing scales and eras: Correlative multimodal microscopy heritage studies
Charles Wood1,2, George Deakin1,2, Atousa Moayedi1,2
1CoMic Research Group, University of Portsmouth, Portsmouth, UK.
Journal of Microscopy
|September 12, 2025
Summary
Correlative Multimodal Microscopy (CoMic) offers advanced, non-invasive analysis for cultural heritage artefacts. This review details CoMic
Area of Science:
- Heritage Science
- Analytical Chemistry
- Materials Science
Background:
- Traditional analytical methods struggle with multi-scale, non-invasive characterization of complex cultural heritage.
- Correlative Multimodal Microscopy (CoMic) integrates diverse techniques for comprehensive artefact analysis.
Purpose of the Study:
- To review the evolution, applications, and future of CoMic in heritage science.
- To provide a roadmap for researchers and conservators utilizing CoMic.
Main Methods:
- Review of historical microscopy in heritage studies.
- Detailed principles of electron, X-ray, optical, and probe microscopies.
- Case studies on wood, pigments, ceramics, metals, and textiles.
Main Results:
- CoMic bridges structural, chemical, and topographical data across length scales.
- Identified challenges include sample prep, data correlation, cost, and expertise.
- CoMic applications span diverse heritage materials.
Conclusions:
- CoMic is transformative for artefact analysis and conservation.
- Future developments require accessible instrumentation, standardized protocols, and AI.
- Widespread adoption will enhance preservation of cultural legacy.
Related Concept Videos
Three-Dimensional Microscopy in Microbiology
777
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
777
Imaging Biological Samples with Optical Microscopy
8.8K
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
8.8K
Two-Dimensional Microscopy in Microbiology
1.1K
Two-dimensional (2D) microscopy encompasses a range of optical techniques that capture images within a single focal plane, offering detailed representations of microscopic structures. These techniques are essential in biological and medical research, enabling the visualization of cellular and subcellular structures with different levels of contrast and specificity.There are several major types of 2D microscopy, each with strengths and applications.Bright-Field MicroscopyBright-field microscopy...
1.1K
Overview of Microscopy Techniques
14.9K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
14.9K
Microbial Morphologies
1.9K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
1.9K
Super-resolution Fluorescence Microscopy
12.2K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
12.2K

