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Updated: Aug 18, 2026
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Inter-tumor Heterogeneity of 68 Ga-PSMA-11 Uptake in Metastatic Undifferentiated Sarcoma
Zhengguang Xiao1, Aisheng Dong2, Yang Wang3
1Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine.
Abstract:
Immunohistochemical studies show PSMA may be a potential target for molecular imaging and treatment in bone and soft tissue sarcomas. We describe 68 Ga-PSMA-11 PET/CT findings in a case with metastatic undifferentiated sarcoma. The sarcoma lesions showed a high variability of 68 Ga-PSMA-11 uptake measured by SUV max , ranging from 3.2 to 21.5. This case indicates that undifferentiated sarcoma can show increased PSMA uptake, 68 Ga-PSMA-11 PET may noninvasively evaluate the inter-tumor heterogeneity of PSMA expression, and PSMA-targeted radioligand therapy may be a promising therapeutic option for this aggressive sarcoma.
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