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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Quantitative fundus autofluorescence in age-related macular degeneration.

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Near-Infrared Fluorescence Lifetime Imaging Microscopy Reveals Loss of RPE Cell Body Polarity in Age-Related Macular Degeneration.

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Updated: Jan 18, 2026

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[Progression assessment for geographic atrophy].

Anna Sophia Jauch1, Marlene Saßmannshausen1, Petrus Chang1

  • 1Augenklinik, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Die Ophthalmologie
|September 12, 2025
PubMed
Summary

Geographic atrophy (GA), a severe stage of age-related macular degeneration (AMD), requires precise quantification for monitoring. Artificial intelligence (AI) offers promising automated methods for assessing GA progression and aiding future therapeutic strategies.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence in Medicine
Keywords:
Age-related macular degeneration (AMD)Artificial intelligenceAutomatic analytical procedureFundus autofluorescence (FAF)Optical coherence tomography (OCT)

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