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Dual-color Correlative Light and Electron Microscopy for the Visualization of Interactions between Mitochondria and Lysosomes
Published on: September 27, 2024
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Mitochondria-lysosome crosstalk in microbial infections
Qianqian He1, Tiantian Huang1, Zhihui Chen1
1School of Life Sciences, Chongqing University, Chongqing, 401331, China.
Science China. Life Sciences
|September 12, 2025
Summary
Mitochondria and lysosomes coordinate cellular defense against pathogens. Their crosstalk, involving the AMP-activated protein kinase (AMPK)-transcription factor EB (TFEB) axis, is vital for immune responses and eliminating microbes.
Area of Science:
- Cellular Biology
- Immunology
- Microbiology
Background:
- Organelle coordination is essential for pathogen resistance.
- Mitochondria and lysosomes maintain cellular homeostasis and immunity.
- Previous studies overlooked mitochondria-lysosome interplay in infections.
Purpose of the Study:
- To review the mechanisms of mitochondria-lysosome crosstalk.
- To highlight the role of the AMPK-TFEB axis in microbial infections.
- To elucidate the impact of this crosstalk on cellular processes during infection.
Main Methods:
- Literature review of existing research on organelle crosstalk and immunity.
- Analysis of the AMP-activated protein kinase (AMPK)-transcription factor EB (TFEB) pathway.
- Synthesis of findings on mitochondria-lysosome interactions in the context of microbial pathogenesis.
Main Results:
- Mitochondria-lysosome crosstalk significantly impacts cellular homeostasis and immune responses.
- The AMPK-TFEB axis is a key regulator in microbial infections.
- This interplay influences critical cellular processes like autophagy and programmed cell death.
Conclusions:
- Mitochondria-lysosome crosstalk is a critical determinant of cellular defense against pathogens.
- Targeting the AMPK-TFEB axis may offer therapeutic strategies for infectious diseases.
- Understanding this crosstalk is crucial for advancing our knowledge of host-pathogen interactions.
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