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Updated: Jun 5, 2026
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Neurodevelopmental Outcomes of Very Low Birth Weight Infants With Transient Hypothyroxinaemia of Prematurity
Sophie S L Yeow1, Charis H Y Chung1, Wilfred H S Wong1
1Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.
Aim:
Transient hypothyroxinaemia of prematurity affects very low birth weight (VLBW) infants born prematurely. The relationship between transient hypothyroxinaemia of prematurity (THOP) and adverse neurodevelopmental outcomes is still controversial. The present study aimed to compare the neurodevelopmental outcomes between those with VLBW infants with THOP and those without.
Methods:
This was a single tertiary neonatal centre retrospective study comparing the neurodevelopmental outcome using Griffiths Mental Development Scales-Extended Revised between VLBW infants (birth weight less than or equal to 1500 g) with THOP to those without based on one-to-one age and gender matching from 2011 to 2021.
Result:
Forty-two VLBW infants with THOP and 42 VLBW infants without THOP were matched by age and gender. None of the infants with THOP received thyroxine supplementation. The prevalence of THOP is 6.86%. The mortality rate for infants with THOP was 14.3%. There was no significant difference in neonatal complications and neurodevelopmental outcomes between infants with THOP (70%) and infants without THOP (70.7%).
Conclusion:
We showed that there was no difference in neurodevelopmental outcomes between those with THOP without thyroxine supplementation and those without THOP.
