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Metabolism-driven posttranslational modifications and immune regulation: Emerging targets for immunotherapy

Gujie Wu1,2, Xiaofei Fan3, Lin Cheng4,5

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Science Advances
|September 12, 2025
PubMed
Summary

Cellular metabolism and immune regulation are deeply intertwined, with metabolite-derived modifications like lactylation regulating immune cell function. Understanding these immunometabolic links offers new therapeutic avenues for diseases.

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