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Updated: Jul 30, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Plasma fibrinogen--a major coronary risk factor
The Journal of the Royal College of General Practitioners
|December 1, 1985
Summary
High plasma fibrinogen levels significantly increase heart attack risk, independent of other factors. This finding highlights fibrinogen as a crucial coronary risk indicator for identifying individuals susceptible to myocardial infarction.
Area of Science:
- Cardiology
- Hematology
- Epidemiology
Background:
- Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
- Identifying reliable indicators of heart attack susceptibility is crucial for preventive strategies.
- Plasma fibrinogen's role as a cardiovascular risk marker requires further elucidation.
Purpose of the Study:
- To investigate the association between plasma fibrinogen levels and the incidence of heart attacks in men without pre-existing CHD.
- To determine if plasma fibrinogen is an independent predictor of heart attack risk.
Main Methods:
- A cohort of 297 men aged 40-69, free from overt CHD at baseline, was observed.
- Plasma fibrinogen levels were measured at the start of the study.
- Follow-up averaged 7.3 years to record new heart attacks.
Main Results:
- A significant positive correlation was observed between initial plasma fibrinogen levels and subsequent heart attack incidence.
- Men with high fibrinogen had a substantially higher heart attack risk, especially when combined with high cholesterol or blood pressure.
- Plasma fibrinogen emerged as a significant and independent predictor of heart attacks, comparable in importance to cholesterol, blood pressure, and smoking.
Conclusions:
- Elevated plasma fibrinogen is a significant independent risk factor for heart attacks.
- Plasma fibrinogen levels should be incorporated into risk assessment profiles for identifying individuals at high risk of myocardial infarction.
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