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Exploring Metabolic Abnormalities of Amino Acids in Preeclampsia-Associated Cardiac Physiological Dysfunction via

Haote Han1,2, Hetong Li1, Qunchen Yuan1

  • 1Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

ACS Nano
|September 12, 2025
PubMed

Insights

Preeclampsia (PE) diagnosis is improved by a new biosensing platform. This technology detects early cardiac dysfunction in pregnant individuals, identifying key molecules and effective treatments.

Area of Science:

  • Cardiovascular Disease Research
  • Biomedical Engineering
  • Reproductive Health

Background:

  • Preeclampsia (PE) presents significant cardiovascular risks during pregnancy.
  • Early cellular-level cardiac dysfunction in PE is difficult to detect with conventional methods.

Purpose of the Study:

  • To develop an advanced biosensing platform for early diagnosis of PE-associated cardiovascular disease.
  • To investigate the impact of PE on cardiomyocyte physiology at the cellular level.

Main Methods:

  • Development of an integrated electrical and optical dynamic cardiomyocyte-based physiology (CBP) biosensing platform.
  • Analysis of cardiomyocyte electrophysiology and calcium handling using patient plasma.
  • Metabolomic analysis of plasma to identify contributing factors.

Main Results:

  • PE patient plasma induced acute electrophysiological and calcium-handling abnormalities in cardiomyocytes.
  • Elevated glycine and serine levels were identified as key contributors to myocardial dysfunction.
  • Coenzyme Q10 intervention demonstrated efficacy in relieving cardiac dysfunction.

Conclusions:

  • The CBP biosensing platform enables precise diagnosis and monitoring of PE-induced myocardial injury.
  • This technology offers a powerful tool for PE-associated cardiological research.
  • The study highlights potential improvements for clinical studies on preeclampsia.

Keywords:
cardiomyocytescoenzyme Q10 interventionmetabolic amino acidmultimodal physiology biosensing systempreeclampsia

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