Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic brain imaging in genetic Parkinson's disease: from genes to network trajectories.

Parkinsonism & related disorders·2026

Same author

Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.

Nature medicine·2026

Same author

Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Investigating AD and non-AD [<sup>18</sup>F]flortaucipir distribution patterns in a memory clinic cohort.

European journal of nuclear medicine and molecular imaging·2026

Same author

Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females.

European journal of nuclear medicine and molecular imaging·2026

Same author

[Chronic coronary syndrome : advanced cardiac imaging].

Revue medicale suisse·2026

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

Published on: November 20, 2018

Visual Classification of Tau-PET Detects 4 Subtypes With Different Long-Term Outcomes.

Cecilia Boccalini¹, Gregory Mathoux², Ines Hristovska³

¹Laboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Switzerland.

|September 12, 2025

Summary

Visual tau-PET classification reliably identified four Alzheimer's disease subtypes with distinct clinical features and outcomes. This method aids in detecting higher-risk variants for personalized diagnosis and treatment.

More Related Videos

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jun 17, 2026

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening

Published on: November 20, 2018

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on ¹⁸F-AV-1451

Published on: April 18, 2025

Area of Science:

Neuroimaging
Alzheimer's Disease Research
Biomarker Discovery

Background:

Alzheimer's disease (AD) exhibits variable tau accumulation patterns.
A data-driven approach identified four distinct tau spatiotemporal trajectories (SuStaIn).
Clinical translation requires a visual method to identify these tau subtypes.

Purpose of the Study:

To establish a standardized visual topographic method for identifying tau patterns using tau-PET.
To validate visual tau subtype classification in a clinical setting.
To assess the clinical utility of visual tau pattern identification.

Main Methods:

Prospective study of 245 individuals with tau-PET scans from a memory clinic.
Classification of tau-PET scans into four subtypes (S1-S4) using visual rating and the SuStain algorithm.
Statistical analysis of inter-rater agreement (Cohen's κ) and differences in clinical/biomarker features between subtypes.

Main Results:

Substantial agreement between raters for visual tau subtype interpretation (κ > 0.65).
Fair agreement between visual and automated tau subtype classification (κ = 0.39).
Visual classification identified subtypes with differing global tau load, clinical features, and cognitive decline rates.

Conclusions:

Visual tau-PET classification reliably identifies four distinct tau patterns in Alzheimer's disease.
These patterns correlate with clinical features and long-term outcomes, indicating clinical usefulness.
This method supports personalized diagnosis and prognosis for higher-risk AD variants.