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Related Concept Videos

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

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Related Experiment Video

Updated: Jul 4, 2026

Monitoring Acupuncture Effects on Human Brain by fMRI
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Acupuncture for Poststroke Cognitive Impairment Based on Default Mode Network Analysis: Protocol for a Randomized

Wangxinjun Cheng1,2, Moyu Wang1,2, Moyi Li1

  • 1Department of Rehabilitation Medicine, First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

JMIR Research Protocols
|September 12, 2025
PubMed
Summary

This study investigates acupuncture for poststroke cognitive impairment (PSCI). Acupuncture may improve cognitive function by modulating the default mode network (DMN), offering a potential non-pharmacological treatment for stroke survivors.

Keywords:
PSCIcognitive functionfMRIfunctional magnetic resonance imagingpoststroke cognitive impairmentrandomized controlled trialtraditional Chinese medicine

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Area of Science:

  • Neuroscience
  • Integrative Medicine
  • Rehabilitation Science

Background:

  • Poststroke cognitive impairment (PSCI) is a common and debilitating consequence of stroke, impacting memory, attention, and executive functions.
  • Current treatments for PSCI are limited, highlighting the need for novel therapeutic strategies.
  • Acupuncture shows potential for cognitive improvement in stroke survivors, but its neural mechanisms, particularly involving the default mode network (DMN), require elucidation.

Purpose of the Study:

  • To evaluate the efficacy of acupuncture in enhancing cognitive function in patients with PSCI.
  • To explore the neurobiological mechanisms of acupuncture's effects on PSCI, focusing on DMN alterations.
  • To utilize multimodal neuroimaging to understand acupuncture's impact on brain networks.

Main Methods:

  • A single-blind, randomized controlled trial involving 54 PSCI patients.
  • Comparison between a standardized scalp acupuncture group and a sham acupuncture control group.
  • Cognitive assessments (MoCA, MMSE) and multimodal neuroimaging (rs-fMRI, DTI) at baseline and follow-up.

Main Results:

  • The study is currently in the recruitment phase.
  • Clinical and neuroimaging data will be analyzed and reported upon trial completion.
  • Results are pending publication.

Conclusions:

  • This protocol aims to clarify acupuncture's efficacy and mechanisms in treating PSCI, emphasizing DMN modulation.
  • Integrating clinical and neuroimaging data will establish objective measures of cognitive improvement.
  • Findings may support acupuncture as a personalized, non-pharmacological neurorehabilitation strategy for cognitive deficits post-stroke.