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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Larynx01:21

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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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HPV16 genomic status stratifies risk of disease recurrence in oropharyngeal squamous cell carcinoma.

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Updated: Jan 18, 2026

Learning Modern Laryngeal Surgery in a Dissection Laboratory
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Radiotherapy for laryngeal cancers: 2025 update.

Audrey Maury1, Mathieu Bosset2, Alexandre Coutte3

  • 1Département de radiothérapie, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 12, 2025
PubMed
Summary

Updated French Society of Radiation Oncology (SFRO) guidelines emphasize personalized radiotherapy for laryngeal cancers. Treatment decisions balance tumor control and laryngeal function preservation, with specific strategies for early and advanced stages.

Keywords:
DelineationDiagnostic imagingDosesDélinéationHypofractionationHypofractionnementImagerie diagnostiqueIndicationsIntensity-modulated conformal radiotherapyLaryngeal tumourRadiothérapie conformationnelle avec modulation d’intensitéRecommandationsRecommendationsSFROSociété française de radiotherapie oncologiqueTumeur du larynx

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Laryngeal Cancer Management

Background:

  • Laryngeal cancer treatment requires careful consideration of tumor stage and patient factors.
  • Accurate assessment of laryngeal mobility is critical for treatment planning.

Purpose of the Study:

  • To present updated recommendations from the Société française de radiothérapie oncologique (SFRO) for laryngeal cancer radiotherapy.
  • To guide therapeutic decision-making for both early and advanced-stage laryngeal cancers.

Main Methods:

  • Clinical examination, including seated position assessment and nasofibroscopy, to evaluate laryngeal mobility.
  • Multidisciplinary discussion for treatment selection in early-stage cancers.
  • Review of established treatment strategies for advanced-stage laryngeal tumors, including chemoradiotherapy and surgery.

Main Results:

  • Personalized treatment selection between surgery and radiotherapy optimizes tumor control and laryngeal function preservation.
  • Standard fractionation is recommended, except for hypofractionation in early-stage glottic tumors.
  • Three-dimensional volumetric imaging is essential for precise patient positioning and monitoring.

Conclusions:

  • Radiotherapy management of laryngeal cancer necessitates consideration of laryngeal mobility.
  • Follow-up care is vital for early recurrence detection, treatment adjustment, and rehabilitation to preserve vocal and respiratory functions.