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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Radiotherapy of skin cancers.

Emmanuelle Le Fur1, Matthieu Pallandre2, Adeline Pêtre3

  • 1Department of Radiation Oncology, Centre armoricain de radiothérapie, imagerie médicale et oncologie, Plérin, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|September 12, 2025
PubMed
Summary

Radiotherapy is a key treatment for many skin cancers, but evidence from randomized trials is limited. Treatment decisions for skin cancer radiation rely on retrospective data and expert consensus.

Keywords:
Basal cell carcinomaCarcinome basocellulaireCarcinome épidermoïde cutanéCutaneous lymphomaCutaneous squamous cell carcinomaGuidelinesKaposi sarcomaLymphome cutanéMelanomaMerkel cell carcinomaMélanomeRecommandationsSFROSociété française de radiothérapie oncologiqueTumeur de KaposiTumeur de Merkel

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Area of Science:

  • Oncology
  • Dermatology
  • Radiation Oncology

Background:

  • Radiation therapy is a treatment option for various histological types of skin cancers.
  • Randomized trials are scarce, limiting definitive evidence for radiotherapy's role and optimal dosing schedules.
  • Current indications are primarily based on retrospective studies and expert opinions.

Purpose of the Study:

  • To review available irradiation techniques for skin cancer.
  • To discuss the indications and techniques for radiotherapy across different skin diseases.
  • To emphasize the importance of multidisciplinary team discussions for complex cases.

Main Methods:

  • Review of existing irradiation techniques.
  • Discussion of indications and techniques specific to each skin disease.
  • Focus on localized skin tumors.

Main Results:

  • The study outlines various radiotherapy techniques applicable to skin cancers.
  • Specific indications and technical considerations for different skin conditions are presented.
  • The heterogeneity of skin cancers necessitates a multidisciplinary approach.

Conclusions:

  • Radiotherapy is a viable option for many skin cancers, particularly localized tumors.
  • Evidence supporting specific dose-fractionation schedules is often limited, relying on retrospective data.
  • Multidisciplinary team consultation is crucial for managing complex or challenging cases, involving visual aids or patient examination.