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Updated: Jan 18, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Cinchona-Alkaloid-Derived NNPP Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones
Xin Meng1, Yunhuan Wang1, Yu Tian1
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004, People's Republic of China.
Abstract:
A series of novel NNPP ligands based on cinchona alkaloids have been developed for the asymmetric hydrogenation of benzophenones, which contain two phosphorus atoms in identical chemical environments. If one phosphorus atom becomes oxidized and is unable to participate in the coordination process, then the other takes its place to ensure that the asymmetric hydrogenation can be completed successfully. The protocol demonstrates excellent catalytic activity and enantioselectivity of up to 99% with various benzophenones (29 examples), including challenging substrates, such as o-aminobenzophenones.
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