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Updated: Jan 18, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment
Ruofei Li1, Zhiwei Qiu2, Yimin Cui1
1Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China; Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.
None:
Glycoprotein VI (GPVI), a key platelet receptor, mediates collagen-induced platelet activation and interacts with fibrin to promote thrombus growth. Studies demonstrate the mechanisms of GPVI in thrombosis, showing its inhibition reduces thrombosis without impairing hemostasis, consistent with the mild bleeding phenotype in GPVI-deficient individuals. GPVI is also implicated in inflammation and cancer. This review introduces the mechanism of GPVI in thrombosis and highlights two investigational GPVI-targeting drugs (glenzocimab and Revacept), summarizing current evidence and future directions for this promising antithrombotic approach.
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