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5xFAD mutations induce hearing impairment in the Ahl-corrected 5xFAD mice
Hongguo Su1, Fan Wu2, Khujista Haque2
1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Experimental Neurology
|September 12, 2025
Summary
Alzheimer
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Neurodegenerative Diseases
Background:
- Age-related hearing impairment (ARHI) is linked to cognitive decline.
- The mechanistic link between ARHI and Alzheimer's disease (AD) dementia is unclear.
Purpose of the Study:
- Investigate the auditory function in a novel AD mouse model (FAD2).
- Explore the relationship between hearing impairment and AD pathology.
Main Methods:
- Developed FAD2 mice with corrected hearing impairment on a 5xFAD background.
- Assessed auditory brainstem response (ABR) thresholds and amplitudes.
- Measured acoustic startle response (ASR) and examined spiral ganglion neuron (SGN) myelin.
Main Results:
- FAD2 mice exhibited elevated ABR thresholds and early auditory nerve hyperexcitability.
- Hearing impairment correlated with early wave I amplitude elevations, not hair cell loss or amyloid.
- SGN myelin degeneration and reduced ASR were observed in FAD2 mice.
Conclusions:
- 5xFAD mutations may cause early auditory nerve hyperexcitability, leading to SGN degeneration and ARHI.
- Early ASR decline suggests central nervous system alterations, potentially indicating early neurodegeneration.
