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N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic

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Psychedelic compounds like N,N-dimethyltryptamine (DMT) alter brain function across the structural connectome. Brain activity changes under DMT correlate with subjective experiences, offering new insights into consciousness.

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Computational Neuroscience

Background:

  • Understanding the brain's structure-function relationship is key to neuroscience.
  • Psychedelics offer unique models to study neurotransmitter effects on perception, cognition, and consciousness.
  • Brain function changes induced by psychedelics propagate across the structural connectome.

Purpose of the Study:

  • To investigate the effects of N,N-dimethyltryptamine (DMT) on brain function within the context of the human connectome.
  • To apply connectome harmonic decomposition to analyze psychedelic-induced alterations in brain activity.
  • To explore the relationship between brain function changes and subjective experience intensity.

Main Methods:

  • Utilized connectome harmonic decomposition, a framework analyzing brain function dependence on network structure.
  • Administered N,N-dimethyltryptamine (DMT) to participants.
  • Measured changes in the connectome harmonic repertoire and repertoire entropy over time.

Main Results:

  • The connectome harmonic repertoire under DMT was significantly reshaped, similar to other psychedelics (psilocybin, LSD, ketamine).
  • Repertoire entropy of connectome harmonics increased under DMT, mirroring effects of other psychedelics.
  • Measures of energy spectrum difference and repertoire entropy of connectome harmonics correlated with subjective experience intensity in real-time.

Conclusions:

  • DMT, like other psychedelics, alters brain function in a manner dependent on the structural connectome.
  • Increased repertoire entropy and energy spectrum difference in connectome harmonics reflect psychedelic states.
  • Connectome harmonic analysis provides a time-resolved index of subjective experience, highlighting a direct link between brain network dynamics and consciousness.