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Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
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Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications

Huan-Yu Zhao1, Jie-Bing Jiang1, Shu-Na Wang1

  • 1Department of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.

Cells
|September 13, 2025
PubMed

Insights

This review explores heart development and cell function, linking cardiogenesis to precision medicine. It highlights breakthroughs in regenerative therapies for cardiovascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Understanding cardiogenesis and heart cell function is crucial for cardiovascular medicine and precision medicine.
  • The heart's development from embryo to maturity involves complex signaling pathways and transcriptional networks.

Purpose of the Study:

  • To comprehensively review heart composition and function from embryonic development to maturity.
  • To highlight breakthroughs in treatment strategies related to cardiac development and cell function.
  • To summarize advancements in gene/cell therapy, organoid development, and regenerative medicine for cardiovascular disease.

Main Methods:

  • Examining spatiotemporally specific signaling pathways driving heart organogenesis.
  • Analyzing transcriptional networks in progenitor cell fate determination.
  • Systematically presenting molecular biomarkers and functional characteristics of mature heart cell types.

Main Results:

  • Detailed elaboration on the molecular mechanisms of cardiac development.
  • Systematic presentation of mature heart cell types' characteristics.
  • Summary of recent advancements in regenerative medicine applications.

Conclusions:

  • Provides a theoretical foundation for precision cardiovascular interventions.
  • Integrates cardiogenesis, cellular architecture, and therapeutic translation for regenerative medicine.
  • Emphasizes breakthroughs in gene/cell therapy, organoid development, and tissue engineering.

Keywords:
cardiac organoidcardiogenesiscell therapygene therapymyocardial cell functionregenerative medicinetissue engineering

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