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Updated: Jan 18, 2026
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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
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Determining Risk Factors Associated with Cardiovascular Complications in Patients with Acute Leukemia: A Systematic
Arezoo Abasi1, Haleh Ayatollahi2, Soroush Rad3
1Student Research Committee, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Cancers
|September 13, 2025
Summary
Cardiovascular complications are common in acute leukemia (AL) patients due to disease and treatment factors. Identifying risk factors like demographics, comorbidities, and genetics aids early detection and better outcomes.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Acute leukemia (AL) patients face increased cardiovascular risks from disease and treatments.
- Complications include heart failure, arrhythmias, myocardial infarction, and thromboembolic events, impacting survival.
Purpose of the Study:
- To identify risk factors for cardiovascular complications in acute leukemia patients.
- To inform risk stratification and monitoring strategies.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Searched multiple databases (PubMed, Scopus, etc.) for studies from 2020-2024.
- Included 75 studies analyzing cardiovascular risk factors in AL patients across subtypes and treatment stages.
Main Results:
- Cardiovascular complications are multifactorial, influenced by demographics, comorbidities (hypertension, diabetes), treatments (anthracyclines, TKIs, HSCT, radiation), and genetic factors.
- Cardiac biomarkers (troponins, BNP), imaging (strain echo), and ECG abnormalities are crucial for detecting subclinical damage.
- Complications manifest during and years after treatment, particularly in childhood and long-term survivors.
Conclusions:
- Cardiovascular complications in AL patients are prevalent and serious.
- A personalized, multidisciplinary approach using clinical, genetic, and biomarker data is essential for risk stratification and monitoring.
- Improved early detection and prevention strategies enhance patient outcomes.
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