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A Novel Nuclear-Localized Micropeptide, MP60, Promotes Hepatocellular Carcinoma Progression via the

Chencheng Li1, Xiu Hong1, Sarra Setrerrahmane2

  • 1Jiangsu Province Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, China Pharmaceutical University, Nanjing 210009, China.

Cancers
|September 13, 2025
PubMed

Insights

We identified MP60, a micropeptide linked to hepatocellular carcinoma (HCC) progression. MP60 promotes tumor growth by interacting with RBM10 and modulating epithelial-mesenchymal transition (EMT), suggesting it as a potential HCC biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genomics

Background:

  • Micropeptides, encoded by non-coding RNAs, are crucial for cellular functions.
  • While some micropeptides are implicated in hepatocellular carcinoma (HCC), their specific roles are not fully understood.
  • This study focuses on MP60, a conserved micropeptide significantly associated with HCC progression.

Purpose of the Study:

  • To identify and characterize novel micropeptides involved in HCC.
  • To investigate the functional role of MP60 in HCC development and progression.
  • To explore MP60 as a potential biomarker and therapeutic target for HCC.

Main Methods:

  • Analysis of The Cancer Genome Atlas (TCGA) dataset to assess coding potential of lncRNAs in HCC.
  • Confirmation of MP60 expression and localization in HCC tissues.
  • Investigation of MP60's interaction with RBM10 and its effect on EMT, proliferation, migration, and adhesion.

Main Results:

  • Identified ENST0000614292 (from LINC01138) as encoding MP60, a 60-amino acid micropeptide.
  • Confirmed MP60 expression in HCC tissues with nuclear localization.
  • MP60 interacts with RBM10, downregulates its expression, modulates EMT, and enhances tumorigenesis in vivo.
  • Elevated MP60 expression correlates with poorer HCC prognosis.

Conclusions:

  • MP60 is a novel oncogenic micropeptide implicated in HCC progression.
  • MP60's oncogenic effects are mediated through RBM10 interaction and EMT modulation.
  • MP60 represents a promising biomarker and therapeutic target for hepatocellular carcinoma.
Keywords:
EMTHCCMP60RBM10micropeptides

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