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Advances in the Regulation of Lipid Metabolism by Non-Coding RNAs
Yongdong Peng1, Anqi Liu1, Qifei Zhu1
1Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, College of Agriculture and Biology, Liaocheng University, Liaocheng 522000, China.
None:
Lipid metabolism is a fundamental biological process that ensures energy homeostasis and cellular integrity. This is an essential and complex biochemical process that is involved in energy storage and the maintaining of normal biological functions. Disorders of lipid metabolism are an urgent health problem, bringing about metabolic syndromes such as obesity, hepatic steatosis, adipose tissue dysfunction, diabetes, cardiovascular diseases, and certain cancers. An increasing body of research has emphasized the pivotal function of ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, in controlling lipid metabolism and associated diseases. To identify novel therapeutic targets, it is necessary to understand the molecular mechanisms by which ncRNAs are involved in the pathobiology of lipid-associated diseases. This review summarizes the research findings on the role of ncRNA in lipid metabolism and the underlying mechanisms, emphasizing their potential as therapeutic targets for lipid-related diseases.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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