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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
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Clinical Utility of eZIS in Cerebral Blood Flow SPECT.

Shinji Yamamoto1, Nobukiyo Yoshida2, Noriko Sakurai3

  • 1Department of Radiological Technology, JCHO Tokyo Yamate Medical Center, Shinjuku 169-0073, Japan.

Diagnostics (Basel, Switzerland)
|September 13, 2025
PubMed
Summary

The easy Z-score Imaging System (eZIS) software offers quantitative analysis for cerebral perfusion SPECT scans. This tool aids in diagnosing Alzheimer's disease and Lewy body dementia by assessing brain blood flow patterns.

Keywords:
99mTc-ECDAlzheimer’s diseaseSPECTeZIS

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Area of Science:

  • Nuclear Medicine
  • Neuroimaging
  • Quantitative Analysis

Background:

  • Cerebral perfusion SPECT (single-photon emission computed tomography) is vital for brain imaging.
  • Visual interpretation of SPECT scans introduces observer subjectivity and variability.
  • Quantitative analysis is needed to improve diagnostic accuracy.

Purpose of the Study:

  • To introduce the easy Z-score Imaging System (eZIS) software for quantitative analysis of cerebral perfusion SPECT.
  • To highlight eZIS's utility in diagnosing neurodegenerative diseases like Alzheimer's and Lewy body dementia.

Main Methods:

  • Utilizes 99mTc-ECD radiopharmaceuticals for SPECT imaging.
  • Compares patient scans to a normal database using Z-scores for quantification.
  • Software received regulatory approval in January 2015.

Main Results:

  • eZIS quantifies cerebral blood flow reduction in characteristic regions for Alzheimer's disease diagnosis (posterior cingulate gyrus, precuneus, parietal lobe).
  • eZIS identifies the "cingulate island sign" for Lewy body dementia diagnosis.
  • Demonstrates significant utility as an auxiliary diagnostic tool.

Conclusions:

  • eZIS provides objective, quantitative analysis of cerebral perfusion SPECT.
  • The software significantly aids in the differential diagnosis of dementia, including Alzheimer's disease and Lewy body dementia.
  • eZIS enhances diagnostic accuracy and reduces subjectivity in SPECT interpretation.