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Updated: Jan 18, 2026

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From Benign Polyp to High-Grade Endometrial Sarcoma: A Case Report with Imaging Correlation

Marina de Miguel Blanc1, Cristina Espada González2, Milagros Gálvez Montes1

  • 1Gynecology and Obstetrics Department, Regional Hospital of Axarquía, 29700 Málaga, Spain.

Diagnostics (Basel, Switzerland)
|September 13, 2025
PubMed
Summary

Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a rare uterine cancer. This case highlights the importance of vigilance for malignant transformation of benign-appearing endometrial lesions, even in asymptomatic patients.

Keywords:
endometrial cancerendometrial sarcomagiant polypgynecologic imaginghysteroscopymagnetic resonance imagingpostmenopause bleedingsarcomatous degenerationultrasound imaginguterine adenosarcoma

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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