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Related Experiment Video

Updated: Jan 18, 2026

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EGFR Amplification in Diffuse Glioma and Its Correlation to Language Tract Integrity.

Alim Emre Basaran1, Alonso Barrantes-Freer2, Max Braune2

  • 1Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany.

Diagnostics (Basel, Switzerland)
|September 13, 2025
PubMed
Summary

Epidermal growth factor receptor (EGFR) amplification in diffuse glioma correlates with reduced white matter integrity in specific language tracts. This finding may impact neurological function and surgical outcomes in patients with EGFR-amplified tumors.

Keywords:
EGFR amplificationdiffuse gliomadiffusion tensor imagingfractional anisotropylanguage tract integrity

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Area of Science:

  • Neuroimaging
  • Neuro-oncology
  • Molecular Pathology

Background:

  • Epidermal growth factor receptor (EGFR) is crucial in diffuse glioma, acting as a biomarker for aggressiveness and a therapeutic target.
  • Diffusion tensor imaging (DTI) reveals microstructural brain changes, complementing molecular pathology by linking imaging to genetic profiles.
  • Understanding EGFR's role via DTI can refine diffuse glioma diagnosis and targeted therapies.

Purpose of the Study:

  • To investigate the relationship between molecular properties of diffuse glioma and DTI findings.
  • To assess if EGFR amplification impacts white matter tract integrity.

Main Methods:

  • 27 diffuse glioma patients (WHO 2021 classification) underwent preoperative DTI.
  • Tractography software DSI Studio reconstructed specific white matter tracts (AF, FAT, IFOF, SLF, UF).
  • Fractional anisotropy (FA) was measured, and EGFR amplification was assessed via molecular pathology.

Main Results:

  • EGFR amplification was found in 29.6% of patients.
  • Lower FA in the left arcuate fasciculus (AF) and left frontal aslant tract (FAT) was significantly associated with EGFR amplification.
  • No significant changes were observed in the right language network.

Conclusions:

  • EGFR amplification may be linked to compromised white matter integrity in left-hemispheric language tracts.
  • This association could affect neurological function and surgical outcomes.
  • Further research is needed to elucidate the molecular mechanisms driving this relationship.