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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
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Age-Based Oocyte Yield in Elective Oocyte Cryopreservation: A Retrospective Cohort Study
Ronit Machtinger1,2, Atalia Tuval3, Ariel Hammerman3
1Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat Gan 52621, Israel.
Diagnostics (Basel, Switzerland)
|September 13, 2025
Summary
This study provides age-based benchmarks for oocyte cryopreservation (OC) yield in healthy women. Real-world data nomograms help set expectations for mature oocyte retrieval and optimize fertility planning.
Area of Science:
- Reproductive Endocrinology
- Biostatistics
- In Vitro Fertilization
Background:
- Increasing demand for elective oocyte cryopreservation (OC) among women delaying childbearing.
- Limited real-world data exists to predict age-specific mature oocyte yield for counseling.
- Need for robust benchmarks to guide patient expectations and treatment planning.
Purpose of the Study:
- To develop age-specific nomograms for predicting mature oocyte yield in elective OC.
- To provide real-world benchmarks for clinicians and patients undergoing fertility preservation.
- To support evidence-based decision-making for women pursuing delayed childbearing.
Main Methods:
- Retrospective analysis of 400 healthy women aged 30-41 undergoing their first elective OC cycle.
- Standardized GnRH antagonist protocol with 300 IU/day gonadotropin.
- Modeling age-specific oocyte yield percentiles using GAMLSS to create nomograms.
Main Results:
- Median total oocytes retrieved: 13; mature oocytes cryopreserved: 10.
- At age 35, 50th percentile yield was 14 total and 11 mature oocytes.
- Nomograms demonstrated a progressive decline in oocyte yield with increasing maternal age.
Conclusions:
- Age-based nomograms from real-world data are valuable for estimating oocyte yield per cycle.
- These tools aid in setting realistic fertility goals and determining the number of OC cycles needed.
- Facilitates shared decision-making and evidence-based counseling for elective oocyte cryopreservation.
