Perovskia atriplicifolia Benth (Russian Sage), a Source of Diterpenes Exerting Antioxidant Activity in Caco-2 Cells
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies novel compounds in Perovskia atriplicifolia, revealing significant antioxidant activity in its diterpenes, including carnosol, carnosic acid, and 1α-hydroxydemethylsalvicanol, important for potential health applications.
Area Of Science
- Phytochemistry
- Natural Product Chemistry
- Pharmacognosy
Background
- Perovskia atriplicifolia is a Persian plant known for its essential oils.
- Limited data exists on the non-volatile compounds of P. atriplicifolia.
- Sesquiterpenes are major components of its essential oil.
Purpose Of The Study
- To investigate the phytochemical profile of P. atriplicifolia aerial parts.
- To identify and quantify non-volatile compounds.
- To evaluate the antioxidant potential of the extract and isolated compounds.
Main Methods
- Phytochemical analysis of the ethanol extract using LC-ESI/QExactive/MS/MS.
- Structural elucidation via Nuclear Magnetic Resonance (NMR) and High-Resolution Mass Spectrometry (HRMS/MS).
- Antioxidant activity assay in Caco-2 intestinal cells.
Main Results
- Phenolics, flavonoids, diterpenes (carnosic acid derivatives), and triterpenes were identified.
- Carnosol, 1α-hydroxydemethylsalvicanol, and carnosic acid were quantified at high concentrations.
- The extract and isolated compounds demonstrated significant free radical scavenging activity.
Conclusions
- The study elucidated the non-volatile phytochemical composition of P. atriplicifolia.
- Diterpenes like carnosol exhibit potent antioxidant properties.
- P. atriplicifolia is a valuable source of bioactive compounds for potential therapeutic use.
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