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Updated: Jan 18, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
Review of Modern Eschweiler-Clarke Methylation Reaction
Xiaoli Zhou1, Xue Ni1, Xianfu Wu1
1National Institutes for Food and Drug Control, Beijing 102629, China.
None:
This paper reviews a substantial amount of research related to the Eschweiler-Clarke methylation reaction, summarizing its mechanism, development, and applications, to present the chemical essence and history of this reaction and its importance and application in modern synthetic chemistry. In particular, this review focuses on advances regarding the Eschweiler-Clarke methylation reaction since 2000. This work will provide researchers with a comprehensive and in-depth perspective of the Eschweiler-Clarke reaction, as well as guidance and inspiration for future research and application.
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