Photopolymerization 3D-Printed Dual-Modal Flexible Sensor for Glucose and pH Monitoring

Area of Science:

• Biomedical Engineering
• Sensor Technology
• Electrochemistry

Background:

• Flexible electrochemical sensors often lack multi-analyte detection capabilities.
• Monitoring multiple physiological parameters like glucose and pH simultaneously is crucial for complex environments.

Purpose of the Study:

• To develop a 3D-printed flexible sensor for synchronous glucose and pH detection.
• To address the limitations of single-parameter detection in current flexible electrochemical sensors.

Main Methods:

• Utilized a 3D-printed ionogel-based microneedle electrode for mechanical robustness.
• Quantified glucose via H2O2 oxidation current (GOD-catalyzed) and pH via polyaniline resistance changes.
• Optimized signal decoupling at 0.2 V for selective detection.

Main Results:

• Achieved synchronous glucose and pH detection with high selectivity.
• Demonstrated a linear glucose response (0.5-2.5 g·L-1) and piecewise-linear pH sensitivity in artificial interstitial fluid.
• Confirmed minimal interference between glucose and pH measurements, ensuring orthogonality.

Conclusions:

• The 3D-printed flexible sensor enables real-time, selective multiparameter monitoring.
• This technology overcomes limitations of single-parameter detection in flexible electrochemical sensors.
• The sensor shows promise for applications requiring simultaneous glucose and pH analysis.