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Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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Carrier-Mediated Transport01:06

Carrier-Mediated Transport

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Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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Related Experiment Video

Updated: Jan 18, 2026

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Cell-Based Drug Delivery Systems: Innovative Drug Transporters for Targeted Therapy.

Shynggys Sergazy1, Kulzhan Berikkhanova1,2, Alexandr Gulyayev1

  • 1National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.

International Journal of Molecular Sciences
|September 13, 2025
PubMed
Summary

Cell-based drug delivery systems show promise for improved targeting and biocompatibility. Future research in hybrid microrobots and artificial cell engineering aims to overcome clinical translation challenges.

Keywords:
cell-based drug deliveryerythrocyte carriersleukocyte delivery systemsplatelet biomimeticstargeted transport

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Cell-based drug delivery systems leverage natural cell properties for enhanced therapeutic outcomes.
  • Various cell types, including erythrocytes, leukocytes, platelets, stem cells, and spermatozoa, are explored as drug carriers.
  • Hybrid microrobots and membrane-coated nanocarriers represent novel biohybrid platforms.

Purpose of the Study:

  • To provide an integrative analysis of recent advancements in cell-based drug delivery systems.
  • To focus on the design, pharmacokinetics, cellular interactions, and therapeutic potential of these systems.
  • To highlight emerging biohybrid platforms like hybrid microrobots and membrane-coated nanocarriers.

Main Methods:

  • Review of the latest scientific literature on cell-based drug delivery.
  • Analysis of design principles, pharmacokinetic profiles, and cellular interactions.
  • Evaluation of therapeutic applications and clinical translation challenges.

Main Results:

  • Significant progress in utilizing diverse cell types for drug delivery.
  • Identification of hybrid microrobots and membrane-coated nanocarriers as promising biohybrid platforms.
  • Persistent challenges include immune clearance, membrane integrity, tissue penetration, and manufacturing.

Conclusions:

  • Cell-based systems offer potential for improved drug targeting, bioavailability, and biocompatibility.
  • Overcoming limitations is crucial for clinical translation.
  • Future directions like CAR-cell combinations and artificial cell engineering hold significant promise for diverse therapeutic areas.