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Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Source And Potency Of Stem Cells

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Related Experiment Video

Updated: Jan 18, 2026

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

Stem Cell Niche Concept: Search for Current Expert Consensus.

Igor Khlusov¹, Larisa Litvinova², Anastasia Efimenko³

¹Department of Morphology and General Pathology, Siberian State Medical University, 634050 Tomsk, Russia.

International Journal of Molecular Sciences

|September 13, 2025

Summary

This summary is machine-generated.

Stem cell niches, crucial for tissue repair, require a standardized definition. This study initiates an expert consensus to refine understanding of stem cell niches, particularly mesenchymal stem cell niches, for regenerative medicine advancement.

Keywords:

bone marrow microenvironment expert consensus hematopoietic stem cells hierarchy mammals mesenchymal stromal/stem cells stem cell niche

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Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

Published on: February 17, 2016

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Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

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Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects

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Published on: February 17, 2016

Area of Science:

Regenerative Medicine
Bioengineering
Stem Cell Biology

Background:

Stem cell niches regulate postnatal stem cell function, including self-renewal and differentiation.
The niche concept is vital for regenerative medicine, bioengineering, and 3D bioprinting.
Inconsistent interpretations of stem cell niche principles hinder scientific progress.

Purpose of the Study:

To establish a consensus on the core principles of stem cell niches.
To develop a standardized framework for understanding stem cell niches.
To address inconsistencies in the interpretation of the stem cell niche concept.

Main Methods:

A consensus-building initiative involving experts in regenerative medicine and bioengineering.
Development and distribution of a questionnaire on niche properties (topography, composition, regulation).
Focus on mesenchymal stem cell niches within the survey.

Main Results:

A pilot survey is underway to gather expert opinions on stem cell niches.
The survey covers key aspects of niche characteristics and regulatory mechanisms.
The initiative aims to standardize the definition and understanding of stem cell niches.

Conclusions:

A unified understanding of stem cell niches is essential for advancing regenerative medicine.
The expert consensus will provide a standardized framework for future research.
This initiative supports the 50th anniversary of the stem cell niche hypothesis.