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Updated: Jan 18, 2026

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Ganglioside Profiling Uncovers Distinct Patterns in High-Risk Neuroblastoma.

Claudia Paret1,2,3,4, Arthur Wingerter1, Larissa Seidmann5

  • 1Department of Pediatric Hematology/Oncology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.

International Journal of Molecular Sciences
|September 13, 2025
PubMed
Summary
This summary is machine-generated.

Ganglioside profiles, especially GD2, can help stratify high-risk neuroblastoma (NBL) patients. Ceramide anchor composition of GD2 may distinguish between low-risk and high-risk NBL, guiding treatment strategies.

Keywords:
B4GALNT1GD2ceramidedinutuximabgangliosidesnaxitamabneuroblastoma

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Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • High-risk neuroblastoma (NBL) treatment faces challenges due to variable outcomes.
  • Gangliosides (GGs), particularly GD2, are key features of NBL and potential biomarkers.

Purpose of the Study:

  • To analyze ganglioside profiles in NBL patient tumors and cell lines.
  • To correlate GG expression with clinical risk, patient outcomes, and gene expression.
  • To identify novel biomarkers for NBL risk stratification and treatment response.

Main Methods:

  • Analysis of ganglioside profiles in 18 patient-derived tumors and 11 NBL cell lines.
  • Utilized thin-layer chromatography and mass spectrometry for GG analysis.
  • Examined expression of 0-, a-, and b-series GGs and correlated with clinical and gene expression data.

Main Results:

  • Low-risk (LR) NBL tumors showed higher levels of complex b-series GGs.
  • Five distinct GG profiles (A-E) were identified in high-risk (HR) NBL tumors.
  • B4GALNT1 gene expression was a prognostic marker; ceramide anchor composition of GD2 differentiated LR and HR NBL.

Conclusions:

  • Ganglioside composition andB4GALNT1 expression are potential biomarkers for NBL risk stratification.
  • GD2 expression and its ceramide anchor may predict treatment response, especially to anti-GD2 therapies.
  • Further research into GG profiles and ceramide synthases could improve NBL patient management.