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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Related Experiment Video

Updated: Jan 18, 2026

Genome-wide Analysis of Histone Modifications Distribution using the Chromatin Immunoprecipitation Sequencing Method in Magnaporthe oryzae
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DNA Methylation in Rice: Mechanisms, Regulatory Roles, and Beyond.

Ting Li1, Wen-Jing Li1,2, Jian-Hong Xu1,2

  • 1Department of Agronomy, College of Agriculture & Biotechnology, Zhejiang University, Hangzhou 310058, China.

International Journal of Molecular Sciences
|September 13, 2025
PubMed
Summary
This summary is machine-generated.

DNA methylation is key to regulating gene expression and plant development in rice. Understanding this epigenetic process can help improve rice yield and stress resilience for global food security.

Keywords:
DNA methylationgenetic improvementgrowth and developmentricestress response

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Area of Science:

  • Epigenetics
  • Plant Molecular Biology
  • Genomics

Background:

  • DNA methylation is a fundamental epigenetic mechanism influencing genomic stability and gene transcription.
  • Rice, a global staple food, requires optimized yield and stress tolerance for food security.
  • Epigenetic regulation via DNA methylation impacts rice growth, development, and environmental responses.

Purpose of the Study:

  • To systematically review DNA methylation mechanisms and detection technologies in rice.
  • To analyze the regulatory roles of DNA methylation in rice growth, development, and stress responses.
  • To provide a theoretical foundation for rice genetic improvement and molecular breeding.

Main Methods:

  • Literature review of DNA methylation studies in rice.
  • Analysis of molecular mechanisms of DNA methylation (de novo, maintenance, demethylation).
  • Examination of advanced DNA methylation detection technologies.

Main Results:

  • DNA methylation dynamically regulates key rice developmental processes like root and grain development.
  • Epigenetic modifications are critical for rice adaptation to environmental stressors (temperature, drought, salinity).
  • DNA methylation patterns are linked to rice domestication and heterosis (hybrid vigor).

Conclusions:

  • Comprehensive understanding of the DNA methylation network is vital for rice genetic improvement.
  • DNA methylation plays a significant role in rice yield, stress tolerance, domestication, and heterosis.
  • This review synthesizes current knowledge to guide future research in rice molecular breeding.