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Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

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Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

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Methods and Guidelines for Metabolism Studies: Applications to Cancer Research.

Melvin Li1,2, Sarah R Amend1,2, Kenneth J Pienta1,2

  • 1Cancer Ecology Center, The James Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

International Journal of Molecular Sciences
|September 13, 2025
PubMed
Summary
This summary is machine-generated.

Cancer cells rewire metabolism to fuel growth and survival, leading to tumor evolution and therapy resistance. This review guides methods to study cancer metabolism and overcome challenges.

Keywords:
13C-metabolic flux analysisSeahorse metabolic flux analysiscancer metabolismfluorescent probesgenetically encoded fluorescent biosensorsisotope tracinguntargeted metabolomics

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Cellular metabolism is a dynamic network essential for growth and homeostasis.
  • Cancer cells exhibit altered metabolic pathways, contributing to tumor heterogeneity and progression.
  • Understanding cancer metabolism is crucial for developing effective therapies.

Purpose of the Study:

  • To review current techniques for studying cancer metabolism.
  • To highlight the application of these methods in cancer research.
  • To discuss challenges and future directions in the field.

Main Methods:

  • Review of established and emerging techniques for metabolic analysis.
  • Comparative analysis of method strengths and limitations.
  • Discussion of experimental design considerations.

Main Results:

  • Characterization of diverse metabolic alterations in cancer.
  • Identification of key metabolic pathways supporting cancer progression.
  • Evaluation of the utility and drawbacks of various methodologies.

Conclusions:

  • Accurate characterization of cancer metabolism requires careful selection of appropriate techniques.
  • Advancements in metabolic research methods are critical for understanding tumor evolution and therapeutic resistance.
  • This review serves as a guide for researchers investigating cancer metabolism.