Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.4K
Lethal Alleles02:41

Lethal Alleles

17.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
17.7K
Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for post-ERCP pancreatitis and assessment of stent exchange intervals in children with chronic pancreatitis: a single-center retrospective study.

BMC pediatrics·2026
Same author

Effects of Dietary Sweet Potato Tuber Meal on Production Performance, Meat Quality and Intestine of Wenchang Chickens.

Biology·2026
Same author

Integrating genomics and transcriptomics to dissect genetic variants associated with feed efficiency and growth traits in chicken.

Poultry science·2026
Same author

Multiple inflammatory cytokines correlate with the vestibular and oculomotor dysfunction in Fabry disease: a prospective, longitudinal study.

Frontiers in immunology·2026
Same author

The cumulative bridge: how long-term physical activity and social engagement gradually enhance sleep health in aging adults.

BMC public health·2026
Same author

A Longitudinal Genome-Wide Association Study Identifies New Candidate Genes for Abdominal Fat Thickness in White Feather Broilers.

Animal genetics·2026

Related Experiment Video

Updated: Jan 18, 2026

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth
06:38

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

Published on: September 20, 2021

2.9K

Identifying New Loci and Genes Associated with Feed Efficiency in Broilers.

Na Luo1, Peihao Liu1, Limin Wei2

  • 1Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Beijing 100193, China.

International Journal of Molecular Sciences
|September 13, 2025
PubMed
Summary
This summary is machine-generated.

Identifying genetic markers for feed efficiency in chickens is crucial for reducing production costs. This study used genome-wide association analyses to pinpoint specific SNPs and genes linked to feed conversion ratio and residual feed intake, aiding broiler breeding advancements.

Keywords:
chicken 55K SNP arrayfeed conversion ratiogenome-wide association studieslongitudinal GWAS (LONG-GWAS)residual feed intake

More Related Videos

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies
05:51

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Published on: June 18, 2020

3.5K
A Hybrid DNA Extraction Method for the Qualitative and Quantitative Assessment of Bacterial Communities from Poultry Production Samples
07:24

A Hybrid DNA Extraction Method for the Qualitative and Quantitative Assessment of Bacterial Communities from Poultry Production Samples

Published on: December 10, 2014

15.0K

Related Experiment Videos

Last Updated: Jan 18, 2026

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth
06:38

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

Published on: September 20, 2021

2.9K
Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies
05:51

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Published on: June 18, 2020

3.5K
A Hybrid DNA Extraction Method for the Qualitative and Quantitative Assessment of Bacterial Communities from Poultry Production Samples
07:24

A Hybrid DNA Extraction Method for the Qualitative and Quantitative Assessment of Bacterial Communities from Poultry Production Samples

Published on: December 10, 2014

15.0K

Area of Science:

  • Animal Genetics
  • Quantitative Genetics
  • Genomic Selection

Background:

  • Feed efficiency is a critical economic trait in broiler production, directly impacting profitability.
  • Optimizing feed efficiency involves reducing feed consumption and enhancing broiler productivity.
  • Identifying genetic factors influencing feed efficiency is essential for targeted breeding programs.

Purpose of the Study:

  • To conduct genome-wide association studies (GWAS) for feed conversion ratio (FCR) and residual feed intake (RFI) in Wenchang chickens.
  • To identify single-nucleotide polymorphisms (SNPs) and candidate genes associated with feed efficiency traits across different growth stages.
  • To explore the genetic architecture of feed efficiency using both single-trait and longitudinal GWAS models.

Main Methods:

  • Utilized 55K SNP microarray data from 4493 Wenchang chickens across two generations.
  • Performed single-trait GWAS and longitudinal GWAS (LONG-GWAS) for FCR and RFI.
  • Annotated genes within ±50 kb of significant loci and analyzed candidate genes using KEGG pathway analysis.

Main Results:

  • Identified 59 SNPs and 36 genes in single-trait GWAS, with candidate loci explaining 1.4-7.0% of phenotypic variance.
  • Discovered 80 SNPs for FCR and 191 SNPs for RFI in LONG-GWAS, annotating 43 and 121 genes, respectively.
  • Highlighted candidate genes enriched in autophagy and mitochondrial phagocytosis pathways, including ANOX3.

Conclusions:

  • The identified SNPs and candidate genes provide valuable genetic resources for improving feed efficiency in chicken breeding.
  • This research offers fundamental insights into the genetic basis of feed efficiency-related traits in chickens.
  • The findings support the development of genomic selection strategies for enhanced broiler production.