Is Radiographic Aftercare Obsolete? How Testing Positive for ctDNA Can Be a Precedent for Late Relapse, Even in
Kerstin Pfister1, Sophia Huesmann1, Angelina Fink1
1Department of Gynecology and Obstetrics, University Hospital Ulm, 89075 Ulm, Germany.
International Journal of Molecular Sciences
|September 13, 2025
Summary
Circulating tumor DNA (ctDNA) detection in low-risk breast cancer patients may precede clinical relapse by years. This case highlights ctDNA
Area of Science:
- Oncology
- Molecular Diagnostics
- Genomics
Background:
- Current breast cancer aftercare often misses early molecular indicators of recurrence.
- Circulating tumor DNA (ctDNA) shows promise in detecting minimal residual disease.
- Evidence for ctDNA in low-risk breast cancer adjuvant settings is limited.


