Related Experiment Video

Updated: Jan 18, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

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Protease-Activated Receptor F2R Is a Potential Target for New Diagnostic/Prognostic and Treatment Applications for

Riya Khetan1, Noor A Lokman2, Preethi Eldi3

  • 1Centre of Pharmaceutical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.

International Journal of Molecular Sciences
|September 13, 2025
PubMed

Insights

Coagulation factor II receptor (F2R) is elevated in ovarian cancers, correlating with metastasis and resistance to chemotherapy. Targeting F2R may offer new theranostic strategies for advanced ovarian cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ovarian cancer treatment faces challenges due to late detection and chemotherapy resistance.
  • Novel molecular targets are crucial for developing advanced theranostic approaches.

Purpose of the Study:

  • To investigate the coagulation factor II receptor/protease-activated receptor 1 (F2R/PAR1) as a diagnostic/prognostic biomarker and therapeutic target in ovarian cancer.

Main Methods:

  • Analysis of public RNA sequence and DNA microarray data for F2R gene expression.
  • Confirmation of F2R protein expression using flow cytometry, immunofluorescence, and immunohistochemistry (IHC).
  • Functional assays to assess the impact of F2R suppression on ovarian cancer cell behavior and drug sensitivity.

Main Results:

  • Elevated F2R mRNA and protein expression were observed in ovarian cancers, particularly in metastatic and chemotherapy-resistant cases.
  • High F2R protein levels were associated with reduced progression-free survival.
  • Suppression of F2R decreased tumor cell motility, invasion, spheroid formation, and metabolism, while increasing carboplatin sensitivity.

Conclusions:

  • F2R represents a promising diagnostic/prognostic biomarker and therapeutic target for ovarian cancer.
  • Targeting F2R could lead to novel theranostic strategies for chemotherapy-resistant and metastatic ovarian cancer.
  • Further research into F2R-targeting therapies, such as antibody-drug conjugates, is warranted.
Keywords:
F2R/PAR1biomarkerdiagnostic/prognosticovarian cancertherapeutic target

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