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The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases
Héctor E López-Valdés1, Martín Hernández-Lucas1, Gustavo D J Rodríguez-Fabián1
1Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City 04360, Mexico.
Abstract:
The anti-aging protein α-Klotho has several therapeutic effects on different pathophysiological conditions, mainly its anti-inflammatory and antioxidant effects. Experimental evidence and observational studies suggest that there are several strategies to increase α-Klotho in the brain and enhance its beneficial effects, thus contributing to improving its neuroprotective and neuroplasticity mechanisms in brain aging, Alzheimer's, Parkinson's, and ischemic stroke diseases. In this article, we summarize the relevant information on α-Klotho, brain aging, Alzheimer's, Parkinson's, and ischemic stroke diseases and analyze the role of α-Klotho in each of these alterations, as well as the effect of physical exercise, exogenous application of α-klotho, and various drugs approved for different human diseases on α-Klotho production.
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