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CD93 in Health and Disease: Bridging Physiological Functions and Clinical Applications

Menghan Cai1, Xiaoxi Zhou1, Songna Wang1

  • 1School of Pharmacy and Laboratory of Drug Discovery from Natural Resources and Industrialization, Macau University of Science and Technology, Macau SAR 999078, China.

International Journal of Molecular Sciences
|September 13, 2025
PubMed

Insights

CD93, a protein on endothelial cells, is crucial for blood vessel formation and cell clearance. Its abnormal expression in diseases like cancer suggests it

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • CD93 is a transmembrane glycoprotein with C-type lectin-like (CTLD) and EGF-like domains.
  • It is primarily expressed in endothelial cells (ECs).
  • CD93 plays roles in angiogenesis, cell adhesion, migration, and apoptotic cell clearance via ligands like MMRN2 and IGFBP7.

Purpose of the Study:

  • To review the structure, function, and disease mechanisms of CD93.
  • To highlight CD93's role in pathological conditions.
  • To discuss CD93 as a potential therapeutic target.

Main Methods:

  • Literature review of CD93 research.
  • Analysis of CD93 expression in various diseases.
  • Examination of CD93's functional domains and interactions.

Main Results:

  • CD93 regulates key physiological processes in ECs.
  • Aberrant CD93 expression is linked to inflammation, cardiovascular diseases, autoimmune disorders, and cancer.
  • Overexpression in tumor vasculature correlates with poor prognosis.

Conclusions:

  • CD93 is a significant regulator of endothelial cell function and a potential biomarker in disease.
  • Targeting CD93 may improve tumor vascular function and immunotherapy efficacy.
  • Further research is needed for clinical translation.

Keywords:
CD93cancerimmune checkpoint inhibitorsimmunotherapytumor angiogenesis

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