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Metabolomic Effects and Their Relationship with Intracellular/Extracellular Concentrations of Casiopeinas® in
Karen Resendiz-Acevedo1, Martha E García-Aguilera2, Araceli Tovar-Tovar3
1Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior s/n, CU, Ciudad de México C.P. 04510, Mexico.
Abstract:
Metal-based compounds, known as metallodrugs, offer promising alternatives for cancers with limited treatment options, such as triple-negative breast cancer (TNBC). Casiopeinas®, a family of copper-based compounds, have shown anticancer and antiproliferative effects both in vitro and in vivo. However, their long-term effects, particularly on metabolic pathways related to invasion and metastasis, remain unknown. This study addresses the sustained impact of Casiopeina IIIia (CasIIIia) and Casiopeina IIgly (CasIIgly) on TNBC cell metabolism, as well as their relationship with intra- and extracellular copper concentrations associated with these compounds. Our results revealed effects on several pathways, including those related to amino acid, lipid, and carbohydrate metabolism and energy production, all of which are involved in epithelial-mesenchymal transition (EMT), invasion, and metastasis. These metabolic changes were accompanied by progressive intracellular accumulation of Casiopeinas®, suggesting a relationship between the concentration and their metabolic effects. These findings suggest that Casiopeinas® could be a promising therapeutic option for TNBC treatment.
Insights
Copper-based metallodrugs, Casiopeinas®, impact triple-negative breast cancer (TNBC) cell metabolism, affecting pathways crucial for invasion and metastasis. Their accumulation correlates with these metabolic changes, suggesting therapeutic potential.
Area of Science:
- Oncology
- Metabolomics
- Medicinal Chemistry
Background:
- Metallodrugs offer novel cancer treatments, especially for triple-negative breast cancer (TNBC).
- Casiopeinas®, copper-based compounds, exhibit anticancer properties.
- Long-term metabolic effects of Casiopeinas® on TNBC invasion and metastasis are not well understood.
Purpose of the Study:
- To investigate the sustained metabolic effects of Casiopeina IIIia (CasIIIia) and Casiopeina IIgly (CasIIgly) on TNBC cells.
- To explore the relationship between intracellular/extracellular copper concentrations and these metabolic changes.
- To assess the potential of Casiopeinas® in targeting TNBC invasion and metastasis.
Main Methods:
- Treatment of TNBC cells with CasIIIia and CasIIgly.
- Analysis of metabolic pathways, including amino acid, lipid, and carbohydrate metabolism, and energy production.
- Monitoring of intracellular and extracellular copper concentrations.
Main Results:
- Casiopeinas® significantly altered metabolic pathways involved in epithelial-mesenchymal transition (EMT), invasion, and metastasis.
- Metabolic changes were linked to progressive intracellular accumulation of the Casiopeinas®.
- A correlation was observed between compound concentration and observed metabolic effects.
Conclusions:
- Casiopeinas® induce sustained metabolic alterations in TNBC cells.
- Intracellular accumulation of Casiopeinas® is associated with their anti-metastatic effects.
- Casiopeinas® show promise as a therapeutic strategy for TNBC.
