Correlation Between Cardiac Troponin Serum Concentration and Selected Parameters of Subclinical Cardiovascular
Grzegorz K Jakubiak1, Monika Starzak2, Natalia Pawlas1
1Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38 St., 41-808 Zabrze, Poland.
Insights
Resting high-sensitivity cardiac troponin T (hs-cTnT) serum concentration correlates with subclinical cardiovascular dysfunction in patients with arterial hypertension (AH). This association is significantly weaker in individuals without AH, suggesting hs-cTnT may screen cardiovascular status in hypertensive patients.
Area of Science:
- Cardiology
- Biomarkers
- Hypertension Research
Background:
- High-sensitivity cardiac troponin T (hs-cTnT) is established for diagnosing acute cardiovascular (CV) disease.
- The utility of resting hs-cTnT for screening subclinical CV dysfunction, particularly in relation to arterial hypertension (AH), remains under investigation.
Purpose of the Study:
- To compare resting hs-cTnT levels with parameters of subclinical CV dysfunction.
- To assess the influence of arterial hypertension (AH) on the relationship between hs-cTnT and subclinical CV dysfunction.
Main Methods:
- 101 patients analyzed using transthoracic echocardiography, Doppler ultrasonography (carotid/lower extremity arteries, intima-media thickness [IMT]), pulse wave velocity (PWV), central blood pressure, ankle-brachial index (ABI), and toe-brachial index (TBI).
- Correlation and multivariate analyses performed to assess relationships between hs-cTnT and CV parameters, stratified by presence of AH.
Main Results:
- In patients with AH, hs-cTnT showed significant correlations with left atrium volume index (LAVI), carotid and femoral IMT, PWV, central systolic blood pressure (cSBP), central pulse pressure (cPP), and ABI.
- Multivariate analysis confirmed significant associations between hs-cTnT and LAVI, cSBP, cPP, and ABI in hypertensive patients.
- The relationship between hs-cTnT and CV parameters was significantly weaker in patients without AH, with only ABI showing a significant correlation.
Conclusions:
- Resting hs-cTnT levels correlate significantly with multiple markers of subclinical cardiovascular dysfunction in patients with arterial hypertension.
- The association between hs-cTnT and subclinical CV dysfunction is markedly attenuated in individuals without AH.
- Further prospective studies are warranted to validate these findings in larger patient cohorts.
Abstract:
Background: High-sensitivity cardiac troponin T serum concentration (hs-cTnT) measurement is a well-established tool in the diagnosis of acute cardiovascular (CV) disease. It remains unclear whether resting hs-cTnT could be useful for screening the status of the CV system. The purpose of this study was to compare the correlation between hs-cTnT, determined in patients without clinical symptoms of acute illness, and selected parameters of subclinical CV dysfunction in relation to the coexistence of arterial hypertension (AH). Methods: In total, 101 patients were included in the analysis. The following methods were used to assess the CV system: transthoracic echocardiography, Doppler ultrasonography of the carotid and lower extremity arteries with intima-media thickness (IMT) measurement, pulse wave velocity (PWV), central blood pressure measurement, ankle-brachial index (ABI), and toe-brachial index (TBI). Results: In patients with AH, significant correlations were found between hs-cTnT and maximal velocity of tricuspid regurgitation (R = 0.397; p = 0.003), left atrium volume index (LAVI) (R = 0.39; p = 0.002), and IMT in carotid arteries (cIMT) (R = 0.4; p = 0.001), common femoral arteries (cfIMT) (R = 0.384; p = 0.004), and superficial femoral arteries (sfIMT) (R = 0.352; p = 0.01), as well as PWV (R = 0.63; p < 0.001), central systolic blood pressure (cSBP) (R = 0.34; p = 0.006), central pulse pressure (cPP) (R = 0.354; p = 0.004), and ankle-brachial index (ABI) (R = -0.28; p = 0.024). In multivariate analysis, the relationship between subclinical CV dysfunction and hs-cTnT remained significant for LAVI, cSBP, cPP, and ABI, as well as showing borderline significance for sfIMT. In patients without AH, only the relationship between hs-cTnT and ABI was significant. According to interaction analysis, AH significantly influenced the relationship between hs-cTnT and cSBP, cPP, and sfIMT. Conclusions: Resting hs-cTnT correlates significantly with selected parameters of subclinical CV dysfunction in patients with AH. This relationship is clearly weaker in patients without AH. Further research is needed, especially prospective studies on a larger group of patients.
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