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The Use of Advanced Glycation End-Product Measurements to Predict Post-Operative Complications After Cardiac Surgery

  • 0School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK.
Journal of Clinical Medicine +

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September 13, 2025

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September 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Advanced glycation end products (AGEs) show a significant association with poor outcomes after cardiac surgery. Measuring AGEs may offer an objective way to assess frailty and improve preoperative risk evaluation.

Area Of Science

  • Biomarkers in Surgery
  • Geriatric Medicine
  • Cardiovascular Research

Background

  • Frailty is a significant factor influencing outcomes in cardiac surgery.
  • Current frailty assessments often rely on subjective measures, impacting reliability.
  • Advanced glycation end products (AGEs) are potential objective biomarkers for frailty.

Purpose Of The Study

  • To review the association between AGEs and surgical outcomes.
  • To evaluate the utility of AGEs for objective frailty assessment.
  • To explore the role of AGEs in preoperative risk stratification for cardiac surgery.

Main Methods

  • Systematic literature search across five databases (MEDLINE, Embase, Cochrane, ClinicalTrials.gov, Google Scholar).
  • Inclusion criteria focused on English-language studies of adult surgical patients; exclusion of incomplete data.
  • Analysis of 13 studies (2402 participants), categorized by surgery type, with quality assessed using ROBINS-I.

Main Results

  • A statistically significant association between AGE levels and post-operative complications/outcomes was found in four of five cardiac surgery studies.
  • This association extended to thoracic and general surgery, correlating with complications and mortality.
  • Pathophysiological mechanisms include AGEs-induced oxidative stress, inflammation, and endothelial dysfunction.

Conclusions

  • Evidence supports a link between AGE levels and cardiac surgical outcomes.
  • AGEs represent a promising objective measure for frailty assessment.
  • Objective frailty measurement using AGEs could enhance preoperative risk assessment and identify candidates for prehabilitation.

Keywords:

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