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Streptococcal enteropathy in infant rats.

D Hoover, S A Bendele, S R Wightman

    Laboratory Animal Science
    |December 1, 1985
    PubMed
    Summary
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    A novel Streptococcus-caused enteropathy led to high mortality in young rats during a toxicity study. This previously unreported rat disease was confirmed by reproducing it through bacterial inoculation.

    Area of Science:

    • Veterinary Pathology
    • Microbiology
    • Toxicology

    Background:

    • A multigeneration toxicity study in rats experienced an unexplained enteric disease outbreak.
    • The disease presented with high morbidity and mortality in preweanling rats.
    • Initial observations revealed gram-positive cocci on intestinal villi without inflammation.

    Purpose of the Study:

    • To identify the causative agent of the enteric disease in rats.
    • To characterize the pathological features of the disease.
    • To confirm the etiological role of the identified bacterium.

    Main Methods:

    • Histopathological examination of affected rat intestines.
    • Ultrastructural analysis to study bacterial morphology and host interaction.

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  • Bacterial isolation, identification, and pure culture cultivation.
  • Experimental reproduction of the disease in healthy rat pups.

    • Main Results:

    • A large number of gram-positive cocci were observed on the surface of small intestinal villi.
    • Ultrastructural studies revealed filamentous attachments between bacteria and between bacteria and microvilli.
    • The causative organism was isolated and identified as Streptococcus sp.
    • Inoculation of dams and newborn pups with Streptococcus successfully reproduced the disease.

    Conclusions:

    • A previously unreported disease, "streptococcal enteropathy," was identified in rats.
    • Streptococcus sp. is the causative agent of this severe enteric disease.
    • The findings highlight the importance of microbial monitoring in toxicity studies.