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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Analysis of comorbidities and chronically used medications in patients with mild cognitive impairment aged 60-74
Andrzej Bożek1, Aleksandra Spyra1, Natalia Tekiela1
1Clinical Department of Internal Diseases and Geriatrics, Medical University of Silesia, Katowice, Poland.
Abstract:
Mild cognitive impairment (MCI) is a condition that may precede the onset of Alzheimer's disease. Of interest are factors that influence the induction of MCI. In this study, we assessed 92 patients with MCI (aged 60-74 years) and 118 controls for comorbidities and medication. In the MCI group, multimorbidity was observed significantly more often. MCI correlated with age, overweight, multimorbidity, the presence of allergic disease, depression, use of sleep medications and tramadol derivatives. The results indicate a higher possibility of MCI in the 60-year-old group, especially in those with multimorbidity and using certain types of drugs.
Insights
Mild cognitive impairment (MCI) is linked to aging, overweight, and multiple health conditions. Certain medications, including tramadol derivatives and sleep aids, also increase MCI risk in older adults.
Area of Science:
- Gerontology
- Neurology
- Clinical Medicine
Background:
- Mild cognitive impairment (MCI) is a potential precursor to Alzheimer's disease.
- Identifying factors influencing MCI development is crucial for early intervention.
- Understanding the role of comorbidities and medications in MCI is an active area of research.
Purpose of the Study:
- To investigate the association between comorbidities, medication use, and mild cognitive impairment (MCI) in adults aged 60-74.
- To identify specific risk factors contributing to the onset of MCI.
Main Methods:
- Cross-sectional study design.
- Involved assessment of 92 patients diagnosed with MCI and 118 healthy controls.
- Data collected on comorbidities and medication usage.
Main Results:
- Multimorbidity was significantly more prevalent in the MCI group compared to controls.
- MCI showed a significant correlation with advanced age, overweight status, and multimorbidity.
- Specific medications, including sleep aids and tramadol derivatives, were associated with MCI, as was the presence of allergic disease and depression.
Conclusions:
- Older adults, particularly those around 60 years old, with multiple health conditions (multimorbidity) and using specific medications, face a higher risk of developing MCI.
- These findings highlight the importance of managing comorbidities and reviewing medication regimens in individuals at risk for cognitive decline.
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